|Isotype||Rabbit polyclonal/Rabbit polyclonal/Mouse IgG1|
|Immunogen||Polyclonal immunoglobulin light chains of kappa and Lamda type isolated from a pool of human sera. Tonsil cells for CD19|
F(ab’)2 Polyclonal Rabbit Anti-Human Kappa Light Chains conjugated with fluorescein isothiocyanate isomer 1 (FITC), F(ab’)2 Polyclonal Rabbit Anti-Human Lambda Light Chains conjugated with R-phycoerythrin (R-PE) and PE-Cynainine 5 Anti-Human CD19 for use in flow cytometry for simultaneous detection and enumeration of kappa light chains and lambda light chains. The conjugate is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide. Each vial contains 50 tests (20 µL of conjugate for up to 106 leucocytes from normal human peripheral blood).
Kappa and Lambda polyclonal have been produced from F(ab')2 fragments of affinity-isolated polyclonal rabbit antibodies. CD19 was purified from Hybridome supernatant.
The evaluation of cell surface Kappa/Lambda expression can identify clonally restricted B lymphocyte populations and thus can aide in the diagnosis of hematologic malignancy. Several B cell disorders are associated with decreased levels of Kappa/Lambda at the cell surface.
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