Product Name : SB 431542 >98% (HPLC)
Cat. No. : CNB201-0050
CAS No. : 301836-41-9
Molecular Formula : C22H16N4O3 Molecular Weight : 384.3875
Target : TGF beta Receptor (TGFBR)
A potent, specific TGF-β type I receptor (ALK5) inhibitor with IC50 of 94 nM; also substantially inhibits ALK4 and 7, but not other ALKs; efficiently inhibits the ability of activated ALK4, ALK5, and ALK7 to phosphorylate Smad2; a selective inhibitor of endogenous activin and TGF-beta signaling but has no effect on BMP signaling, and has no effect on components of the ERK, JNK, or p38 MAP kinase pathways.
Caution: Product has not been fully validated for medical applications. Lab Use Only!