CNB201-0050 / SB 431542 >98% (HPLC)


CNB201-0050 / SB 431542 >98% (HPLC)

아이셀 0 396 2018.07.24 17:40

Product Name : SB 431542 >98% (HPLC) 

Cat. No. : CNB201-0050 

CAS No. : 301836-41-9 

Molecular Formula : C22H16N4O3 Molecular Weight : 384.3875 

Target : TGF beta Receptor (TGFBR) 

Biological Activity 

A potent, specific TGF-β type I receptor (ALK5) inhibitor with IC50 of 94 nM; also substantially inhibits ALK4 and 7, but not other ALKs; efficiently inhibits the ability of activated ALK4, ALK5, and ALK7 to phosphorylate Smad2; a selective inhibitor of endogenous activin and TGF-beta signaling but has no effect on BMP signaling, and has no effect on components of the ERK, JNK, or p38 MAP kinase pathways. 

Caution: Product has not been fully validated for medical applications. Lab Use Only! 


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