CNP204-0005 / PAF C-16

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Catalog Number : CNP204-0005

CAS Registry No.: 74389-68-7

Formal Name: PAF C-16, ≥ 98.0%

Synonym: β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine hydrate

MF: C26H54NO7P

FW: 523.7

Purity: ≥98%

Stability: ≥1 year at -20°C

Supplied as: A lyophilized powder

Laboratory Procedures

For long term storage, we suggest that PAF C-16 be stored as supplied at -20°C, preferably in a desiccator. It

will be stable for at least one year.

PAF C-16 is supplied as a lyophilized powder. A stock solution may be made by dissolving the PAF C-16 in

an organic solvent purged with an inert gas. PAF C-16 is soluble in organic solvents such as ethanol, DMSO,

and dimethyl formamide. The solubility of PAF C-16 in these solvents is approximately 10 mg/ml.

Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to

performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since

organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous

solutions of PAF C-16 can be prepared by directly dissolving the lyophilized powder in aqueous buffers. The

solubility of PAF C-16 in PBS, pH 7.2, is approximately 25 mg/ml. We do not recommend storing the

aqueous solution for more than one day.

PAF C-16 is a phospholipid synthesized by stimulated endothelial cells, neutrophils, basophils, eosinophils,

and macrophages.1,2 In addition to activation of platelets, PAF C-16 also activates neutrophils, monocytes,

and macrophages. Its receptor mediated biological actions are achieved at concentrations as low as 10-12