COLCOM

Implementation

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Activities / Implementation 

For you, we are mobilizing our expertise and unique technology regarding the various possibilities of implementation of DGL :
surface or core functionalization, grafting on supports, etc. The different generations of DGL and their high number of modification possibilities offer to our society a real multi-purpose use platform. For this, or for any other information, please contact us: info@colcom.eu.

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237106708_t3QCsSYT_d684a3898f508d1c8bcdd4183350965231410695.jpg
237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
Scheme

237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif

Functionalized DGL :

Amino groups on the surface can be grafted by other functions such as CO2H, SO3H, PO3H, sugars, PEO, antibodies, etc. Thus, cationic DGL can be converted to anionic, neutral, hydrophilic or hydrophobic molecules.

 

 

237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif 

237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
237106708_t3QCsSYT_d684a3898f508d1c8bcdd4183350965231410695.jpg
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237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
Scheme
237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
237106708_t3QCsSYT_d684a3898f508d1c8bcdd4183350965231410695.jpg
237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
Scheme

237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif

DGL with tag :

It is also possible to encapsulate a fluorescent molecule (tag) in a DGL by binding it covalently to the DGL core. The complex DGL-fluorescein thus formed remains a biocompatible and non immunogenic product (in particular for applications in medical imagery).

By grafting a specific hapten at the surface of the DGL (multifunctional), a new complex DGL-fluorescein-hapten can be obtained and used to visualize a specific receptor.

237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif 

237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
237106708_t3QCsSYT_d684a3898f508d1c8bcdd4183350965231410695.jpg
237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif
Scheme

237106708_FaWbpENS_9d6d508448a3197b7ed32d5d250337cb664b1dac.gif

DGL on supports :

Grafting of the DGL (cationic, anionic, etc.) on various solid supports leads to functionalized surfaces. This enlarges the field of applications of these original molecular tools.

237106708_OdFSa0cq_90b8e2277ddfd5791ea53889220ebe3e63e8adce.jpgComplex DGL-G3/fluorescein grafted
on silica particles of 50 µm.

 

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