"The field has done well at producing technologies to serve as hit-identification plattforms. But it would be nice to try to identify lead-quality matter: ligands that have a certain affinity for a target and that also have desirable pharmacokinetic attributes for cell permeability
and oral bioavailability.“
Spiros Liras VP CV, MD Pfizer, from: Kotz, J. Bringing macrocycles full circle.
SciBX 2013, 5, doi:10.1038/scibx.2012.1176
Macrocyclic Compounds (MACROx) available off-the-shelf:
> 1000 Macrocyclic Semi-Synthetic Compounds from 6 Scaffolds